Filling the Void: A Low Cost, High-Yield Method to Addressing Incidental Findings in Trauma Patients

In this study we: Report the incidence of incidental findings in a suburban trauma center treating primarily blunt and elderly trauma Propose simple solutions to increase the rate of disclosure to patientshttps://jdc.jefferson.edu/patientsafetyposters/1070/thumbnail.jp

Linking solar and long baseline terrestrial neutrino experiments

We show that in the framework of three light neutrino species with hierarchical masses and assuming no fine tuning between the entries of the neutrino mass matrix, one can use the solar neutrino data to obtain information on the element $U_{e3}$ of the lepton mixing matrix. Conversely, a measurement of $U_{e3}$ in atmospheric or long baseline accelerator or reactor neutrino experiments would help discriminate between possible oscillation solutions of the solar neutrino problem.Comment: revtex, 4 pages, no figures. Discussion of the LOW solution modified; results unchanged. References adde

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer

Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [18F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy. Results: Breast tumour SUVmax of [18F]ICMT-11 was low at baseline and unchanged following therapy. Measurement of M30/M60 cytokeratin-18 cleavage products showed that therapy was predominantly not apoptosis in nature. While increases in caspase-3 staining on breast histology were seen, post-treatment caspase-3 positivity values were only approximately 1%; this low level of caspase-3 could have limited sensitive detection by [18F]ICMT-11-PET. Fourteen out of 15 breast cancer patients responded to first–line chemotherapy (complete or partial response); one patient had stable disease. Four patients showed increases in regions of high tumour [18F]ICMT-11 intensity on voxel-wise analysis of tumour data (classed as PADS); response was not exclusive to patients with this phenotype. In patients with lung cancer, multi-parametric [18F]ICMT-11 PET and MRI (diffusion-weighted- and dynamic contrast enhanced-MRI) showed that PET changes were concordant with cell death in the absence of significant perfusion changes. Conclusion: This study highlights the potential use of [18F]ICMT-11 PET as a promising candidate for non-invasive imaging of caspase3/7 activation, and the difficulties encountered in assessing early-treatment responses. We summarize that tumour response could occur in the absence of predominant chemotherapy-induced caspase-3/7 activation measured non-invasively across entire tumour lesions in patients with breast and lung cancer

Generalised Hong-Ou-Mandel Experiments with Bosons and Fermions

The Hong-Ou-Mandel (HOM) dip plays an important role in recent linear optics experiments. It is crucial for quantum computing with photons and can be used to characterise the quality of single photon sources and linear optics setups. In this paper, we consider generalised HOM experiments with $N$ bosons or fermions passing simultaneously through a symmetric Bell multiport beam splitter. It is shown that for even numbers of bosons, the HOM dip occurs naturally in the coincidence detection in the output ports. In contrast, fermions always leave the setup separately exhibiting perfect coincidence detection. Our results can be used to verify or employ the quantum statistics of particles experimentally.Comment: 11 pages, 2 figures, more references adde

Creation, doubling, and splitting, of vortices in intracavity second harmonic generation

We demonstrate generation and frequency doubling of unit charge vortices in a linear astigmatic resonator. Topological instability of the double charge harmonic vortices leads to well separated vortex cores that are shown to rotate, and become anisotropic, as the resonator is tuned across resonance

The Child Brain Computes and Utilizes Internalized Maternal Choices

As children grow, they gradually learn how to make decisions independently. However, decisions like choosing healthy but less-tasty foods can be challenging for children whose self-regulation and executive cognitive functions are still maturing. We propose a computational decision-making process in which children estimate their mother's choices for them as well as their individual food preferences. By employing functional magnetic resonance imaging during real food choices, we find that the ventromedial prefrontal cortex (vmPFC) encodes children's own preferences and the left dorsolateral prefrontal cortex (dlPFC) encodes the projected mom's choices for them at the time of children's choice. Also, the left dlPFC region shows an inhibitory functional connectivity with the vmPFC at the time of children's own choice. Our study suggests that in part, children utilize their perceived caregiver's choices when making choices for themselves, which may serve as an external regulator of decision-making, leading to optimal healthy decisions

Interaction-dependent photon-assisted tunneling in optical lattices: a quantum simulator of strongly-correlated electrons and dynamical gauge fields

We introduce a scheme that combines photon-assisted tunneling by a moving optical lattice with strong Hubbard interactions, and allows for the quantum simulation of paradigmatic quantum many-body models. We show that, in a certain regime, this quantum simulator yields an effective Hubbard Hamiltonian with tunable bond-charge interactions, a model studied in the context of strongly-correlated electrons. In a different regime, we show how to exploit a correlated destruction of tunneling to explore Nagaoka ferromagnetism at finite Hubbard repulsion. By changing the photon-assisted tunneling parameters, we can also obtain a t-J model with independently controllable tunneling t, super-exchange interaction J, and even a Heisenberg-Ising anisotropy. Hence, the full phase diagram of this paradigmatic model becomes accessible to cold-atom experiments, departing from the region t _ J allowed by standard single-band Hubbard Hamiltonians in the strong-repulsion limit. We finally show that, by generalizing the photon-assisted tunneling scheme, the quantum simulator yields models of dynamical Gauge fields, where atoms of a given electronic state dress the tunneling of the atoms with a different internal state, leading to Peierls phases that mimic a dynamical magnetic field

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).

AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitrite (n = 118) or matching placebo (n = 111) over 5 min immediately before primary percutaneous intervention (PPCI). Patients underwent cardiac magnetic resonance imaging (CMR) at 6-8 days and at 6 months and serial blood sampling was performed over 72 h for the measurement of plasma creatine kinase (CK) and Troponin I. Myocardial infarct size (extent of late gadolinium enhancement at 6-8 days by CMR-the primary endpoint) did not differ between nitrite and placebo groups after adjustment for area at risk, diabetes status, and centre (effect size -0.7% 95% CI: -2.2%, +0.7%; P = 0.34). There were no significant differences in any of the secondary endpoints, including plasma troponin I and CK area under the curve, left ventricular volumes (LV), and ejection fraction (EF) measured at 6-8 days and at 6 months and final infarct size (FIS) measured at 6 months. CONCLUSIONS: Sodium nitrite administered intravenously immediately prior to reperfusion in patients with acute STEMI does not reduce infarct size

Optically Thick Radio Cores of Narrow-Waist Bipolar Nebulae

We report our search for optically thick radio cores in sixteen narrow-waist bipolar nebulae. Optically thick cores are a characteristic signature of collimated ionized winds. Eleven northern nebulae were observed with the Very Large Array (VLA) at 1.3 cm and 0.7 cm, and five southern nebulae were observed with the Australia Telescope Compact Array (ATCA) at 6 cm and 3.6 cm. Two northern objects, 19W32 and M 1-91, and three southern objects, He 2-25, He 2-84 and Mz 3, were found to exhibit a compact radio core with a rising spectrum consistent with an ionized jet. Such jets have been seen in M 2-9 and may be responsible for shaping bipolar structure in planetary nebulae.Comment: 29 pages, accepted for publication in Ap

Noise auto-correlation spectroscopy with coherent Raman scattering

Ultrafast lasers have become one of the most powerful tools in coherent nonlinear optical spectroscopy. Short pulses enable direct observation of fast molecular dynamics, whereas broad spectral bandwidth offers ways of controlling nonlinear optical processes by means of quantum interferences. Special care is usually taken to preserve the coherence of laser pulses as it determines the accuracy of a spectroscopic measurement. Here we present a new approach to coherent Raman spectroscopy based on deliberately introduced noise, which increases the spectral resolution, robustness and efficiency. We probe laser induced molecular vibrations using a broadband laser pulse with intentionally randomized amplitude and phase. The vibrational resonances result in and are identified through the appearance of intensity correlations in the noisy spectrum of coherently scattered photons. Spectral resolution is neither limited by the pulse bandwidth, nor sensitive to the quality of the temporal and spectral profile of the pulses. This is particularly attractive for the applications in microscopy, biological imaging and remote sensing, where dispersion and scattering properties of the medium often undermine the applicability of ultrafast lasers. The proposed method combines the efficiency and resolution of a coherent process with the robustness of incoherent light. As we demonstrate here, it can be implemented by simply destroying the coherence of a laser pulse, and without any elaborate temporal scanning or spectral shaping commonly required by the frequency-resolved spectroscopic methods with ultrashort pulses.Comment: To appear in Nature Physic